Spine

Solvay’s Ixef® PARA enables Intelligent Implant Systems to pioneer a new single-use instrument kit for anterior cervical fusion procedures

Alpharetta, Ga., September 26, 2018 — Solvay, a leading global supplier of specialty polymers, announced today that the high stiffness, strength, gamma sterilization resistance and biocompatibility of its Ixef® polyacrylamide (PARA) resin helped enable a new single-use instrument kit for anterior cervical fusion procedures. Developed by Intelligent Implant Systems, a medical device company specializing in solutions for spinal surgery, the MEDIANT™ Anterior Cervical Plating System leverages Solvay’s advanced polymer to help boost operating room (OR) efficiency, eliminate onsite sterile processing and reduce infection risk.

“The primary benefit of Solvay’s Ixef® PARA in this application is its metal-like strength, which gives our single-use surgical instruments a very high level of performance without incurring the costs associated with machining metal and repeated steam sterilization,” said Marc Richelsoph, president and CEO of Intelligent Implant Systems. “Although PEI also offered viable options for our surgical tool kit, we specified Ixef® GS-1022 PARA because its superior stiffness and moldability was essential for the kit’s instruments.”

Ixef® GS-1022 PARA forms the awl and pin-screwdriver handles, measuring caliper, and locking plier handles in Intelligent Implant Systems’ kit. The polymer’s excellent impact resistance also eliminated the need for a metal strike plate that had been part of the awl’s early designs. This reduced the cost and simplified the manufacture and assembly of the instrument, further supporting the economics of single-use instruments.

Ixef® GS-1022 PARA provides excellent aesthetics, including an attractive surface finish. The material is available in a range of gamma-stabilized colors, including the signature green of the MEDIANT™ System’s tools. Together, these properties of Ixef® PARA ensure Intelligent Implant Systems’ single-use instruments retain their visual appeal after they are gamma sterilized and packaged for delivery. Solvay’s PARA polymer has been evaluated for ISO 10993 limited duration biocompatibility and is supported by an FDA Master Access File, which helped streamline the MEDIANT™ kit’s navigation through regulatory approvals.

“Solvay was an early advocate of the healthcare industry’s shift toward single-use surgical instruments, and we sought to support customers by proactively developing a broad portfolio of biocompatible polymer alternatives to metal – complete with gamma-sterilized colors and master access files,” said Jeff Hrivnak, business manager for Healthcare at Solvay’s Specialty Polymers Global Business Unit. “Yet while the industry’s growing adoption of our advanced polymers validates this early insight, we derive much greater satisfaction in working closely with innovators like Intelligent Implant Systems to help achieve unique new designs for improving patient results.”

Intelligent Implant Systems will feature the MEDIANT™ Anterior Cervical Plating System at Booth #1905 during The North American Spine Society (NASS) meeting in Los Angeles, Sept. 26-29. For related news about specialty polymers for healthcare, please go to www.solvayhealthcarenews.com.

® Ixef is a registered trademark of Solvay

™ MEDIANT is a trademark of Intelligent Implant Systems

Intelligent Implant Systems is based in Charlotte, NC. Founded in 2007, the company aims to develop and market innovative surgical solutions for orthopedics and both fusion and non-fusion applications of the spine. Since its inception, the company has been granted multiple U.S. patents with foreign and additional U.S. patents pending to protect its core technology. Innovation is truly part of what Intelligent Implant Systems brings to patients, surgeons, hospitals and ambulatory surgery centers. Learn more at www.intelligentimplantsystems.com.

Media Relations

Marla Witbrod
Solvay Specialty Polymers
+1 770 772 8451
marla.witbrod@solvay.com

Dan McCarthy
AH&M Marketing Communications
+1 413 448 2260 Ext. 470
dmccarthy@ahminc.com

Enrico Zanini
Solvay Specialty Polymers
+39 338 603 4561
enrico.zanini@solvay.com

Alan Flower

Industrial Media Relations

+32 474 117 091

alan.flower@indmr.com

 

 

 

 

 

 

Surgio and SimplyRFID Announce Partnership For Fully-Automated Visibility into the Medical Device Supply Chain in Healthcare

Surg.io™, an emerging leader in software solutions for the management of orthopedic instrument and implant inventory as well as hospital sterile processing and perioperative solutions, has partnered with SimplyRFID, a veteran leader in tracking technology and inventory visibility solutions, announce an exclusive healthcare partnership to provide a fully integrated inventory management system that brings real-time visibility, tracking, and analytics to the entire hospital supply chain.

The medical device supply chain is inherently complex and full transparency has remained elusive for the majority of the healthcare industry. Hospitals and manufacturers alike have difficulty gaining oversight of even their highest-dollar assets.

Recent studies and surveys show that 80% of hospitals still manage their inventory via manual processes. Without tracking, up to 30% of their inventory expires on the shelves and hundreds of thousands – and often millions – of dollars in charges go uncaptured and unnecessary purchasing practices continue unabated.

The agreement combines two technology platforms that enable real-time location tracking plus artificial intelligence to reduce the potential for human error while increasing supply chain efficiencies. Surg.io and Simply RFID have jointly created the most advanced software/hardware solution to provide transparency and actionable analytics to the orthopedic & spine clinical arenas.

The new partners plan to launch the products in Los Angeles this week at the North American Spine Society’s Annual Convention on September 26-19 (Booth 1135). “We are excited to see how the partnership of Surg.io and SimplyRFID takes both platforms to new heights that were previously impossible. It is a real ‘1 plus 1 = 10’ scenario.” Jeff Claeson, Surg.io’s Co-Founder & Chief Technology Officer.

Carl Brown, President/Founder of SimplyRFiD said: “It’s a perfect match! Surgio makes healthcare supply chain management simple. We make supply chain tracking simple. By bringing these two technologies together – a trusted hospital scheduling / management product from Surgio and an accurate tracking system from SimplyRFiD – we give hospitals the best solution for managing their resources. Together, we create the complete solution that improves healthcare for everyone.”

About Surg.io

Surg.io is a complete inventory tracking system created for the orthopedic and spine industry. ERP systems were not built to effectively facilitate the fast-paced logistical environment of medical device supply chains. They are complex and often rely on tribal knowledge of each system to manage effectively. Healthcare suppliers and institutions rely on Surg.io to streamline communication between disparate teams to ensure continuity. By offering a user-friendly and intuitive interface, you don’t have to be a power user to manage inventory. Leverage Surg.io to enhance processes and optimize supply chain strategy.

About SimplyRFID

Since its founding in 2003, SimplyRFID has been at the forefront of developing tracking technology software. With over 100 million tags shipped and thousands of systems deployed worldwide in industries ranging from defense to healthcare, SimplyRFID is the expert industry leaders turn to for tracking solutions. Its largest deployment was developed in support of a major pharma group, which chose SimplyRFID due to its 15+ years of industry-leading expertise in RF-data capture solutions.  The deployment created a solution with unmatched reliability, accuracy, and scalability, enabling real-time tracking of tagged pharmaceutical items in hospitals and at healthcare providers worldwide.

 

Medacta Appoints General Manager for U.S. Spine Business and Announces Full-Market Release of Customizable MySpine MC Surgical Guides for Posterior Lumbar Fusions

LOS ANGELES–(BUSINESS WIRE)–Medacta® International, the family-owned global leader in innovative joint replacement and spinal technologies, announces today the appointment of long-time commercial leader Daniel Abromowitz as General Manager, Spine Division for Medacta USA. In addition, the company announced its MySpine Midline Cortical Pedicle Screw Placement Guide (MySpine MC), a patient-matched technology for posterior lumbar fusions, is now generally available and will be on display at the North American Spine Society (NASS) 2018 Annual Meeting, held Sept. 26-29, 2018 in Los Angeles, at Booth #2323.

“Daniel is a welcomed addition to the management team, bringing an innovative management approach and broad engineering and supply chain experience,” said Eric Dremel, President of Medacta USA. “Most importantly, Daniel’s track record of sustained commercial success and relentless customer focus will allow the potential of our Spine Division to be fully realized.”

A respected business leader, Abromowitz brings to Medacta USA a history of building high-performing, results-driven teams, with more than a decade of experience supporting and leading early-stage and emerging companies in the medical device and health care marketplaces. After nine years with spinal implant company X-spine Systems, Inc., Daniel was the Vice President of Sales when the company was acquired by Bacterin in 2015. Since, he has held senior leadership positions at Xtant Medical (formerly X-spine), Aerobiotix and most recently, Captiva Spine.

“As a passionate supporter of collaborative worldwide innovation, Medacta International offers an incredible growth opportunity for spine in the U.S. market. My goal is to build on the successful foundation of Medacta’s joint division here in the U.S. to support our key stakeholders in spine: surgeons, patients, facilities and agents,” Abromowitz said. “By utilizing the Medacta Orthopaedic Research and Education (M.O.R.E.) Institute, Medacta surgeons are never alone. I hope to expand on these peer-to-peer training programs for spinal surgeons here in the U.S., as we build Medacta USA Spine into an innovative leader for the U.S. market.”

MySpine MC – Offering a new approach to posterior lumbar fusion

The patient-matched, 3D-printed MySpine MC, first announced in May 2018, guides pedicle screws to a trajectory that evolved from the well-established cortical bone trajectory (CBT). The MySpine MC technique, however, has a more caudomedial entry point than traditional pedicle screw trajectories and a less extreme caudal-cranial angle than CBT to avoid interference with the cranial facet joints and to accommodate larger screw diameters and lengths, precisely supported by 3D pre-operative planning. As an accurate and reliable muscle-sparring approach, MySpine MC is designed to encourage faster patient recovery and is suitable for both inpatient and outpatient surgery settings.

MySpine MC will be on display at NASS 2018 at Booth #2323 along with the rest of Medacta’s spine product portfolio. For more information on MySpine MC, visit Medacta’s MySpine MC webpage, where the new MySpine MC video is available.

About Medacta International

Medacta® International is a world leading manufacturer of orthopedic implants, neurosurgical systems, and instrumentation. Medacta’s revolutionary approach and responsible innovation have resulted in standard of care breakthroughs in hip replacement with the AMIS® system and total knee replacement with MyKnee® patient-matched technology. Over the last 10 years, Medacta has grown dramatically by taking a different approach and placing value on all aspects of the care experience from design to training to sustainability. Medacta is headquartered in Castel San Pietro, Switzerland, and operates in over 30 countries. To learn more about Medacta International, please visit www.medacta.com or follow @Medacta on Twitter.

Contacts

For Medacta International
Jill Bongiorni, 516-729-2250
Jill@torchcomllc.com

SurGenTec’s ALARA™ Access Needle Awarded Best Spine Technology for 2018

BOCA RATON, Fla.–(BUSINESS WIRE)–SurGenTec ® LLC, a South Florida based medical device company has been awarded the 2018 Orthopedics This Week Spine Technology Award and will be formally receiving their award during the 2018 North American Spine Society meeting. This year’s meeting will be held Sept. 26th -28th in Los Angeles, CA. The awarded technology from SurGenTec’s product line is the unique and innovative ALARA ™ access needle. The access needle will be offered in multiple variations including with and without a depth stop. When combined with their patented fully adjustable extension handle the user can maintain superior target needle manipulation while also reducing radiation exposure. The extension handle allows users to maintain maximum source-to-skin distance between their hands and the primary x-ray beam without sacrificing precision and control. A white paper study revealed a reduction in radiation exposure of 293 times less than standard needle manipulation and 15 times less than using a Kocher Clamp. The ALARA access needle is set for release in Mid-October.

Travis Greenhalgh, CEO of SurGenTec stated in a recent interview, “Although its often overlooked in the industry, many surgeons reach dangerous levels of radiation exposure annually and SurGenTec is on a mission to decrease those numbers and raise awareness.”

SurGenTec, LLC is a medical device company based in Boca Raton, FL that strives to bring the next level of technology to the spine and orthopedic industry. SurGenTec develops and manufactures innovative products with patient and surgeon safety at the heart of everything they develop. SurGenTec has already made their presence known with the GraftGun® Universal Graft Delivery System which launched earlier this year and are excited to add the awarded ALARA to their portfolio. SurGenTec will also be showcasing their pre-filled MIS cartridge options at NASS, including ViBone® viable bone matrix. SurGenTec partnered with Aziyo® Biologics to provide ViBone next generation bone graft in an MIS cartridge to reduce thawing time, cross contamination, and delivery issues. SurGenTec has multiple products in their pipeline set for release over the next year.

www.surgentec.com
7601 N Federal Hwy., Suite 150A
Boca Raton, FL 33487
561-990-7882 / customerservice@surgentec.com

Contacts

SurGenTec ® LLC
Ricki Goldman, 561-990-7882
customerservice@surgentec.com

MATRIXX: First Ever Clinical Trial Evaluating 3D-Printed Titanium vs PEEK

September 24, 2018

NOBLESVILLE, Ind.–(BUSINESS WIRE)–Nexxt Spine LLC, a medical device company focused on designing, manufacturing, and distributing innovative spinal solutions, announces the momentous start of the MATRIXX Trial – marking the first ever clinical evaluation of novel 3D-printed lumbar interbody fusion devices relative to PEEK.

The Nexxt Matrixx® System is a collection of porous titanium spinal fusion implants that interweave highly differentiated surface texturing technology with novel 3D-printed cellular scaffolding. With the sponsorship of this trial, Nexxt Spine hopes to prove that their technology can accelerate bony ingrowth and improve clinical outcomes.

“Since we launched last October, over 1400 Nexxt Matrixx® devices have been implanted and the response from our surgeon leaders has been phenomenal,” stated Nexxt Spine President, Andy Elsbury. “While our early adopters have witnessed improved clinical outcomes first-hand, we are excited to take the industry lead and quantify the clinical merits of Nexxt Matrixx® scientifically.”

The MATRIXX Trial is a prospective randomized controlled trial that will evaluate the clinical and radiographic outcomes of the Nexxt Matrixx® System following lumbar interbody fusion. Patients will be randomized to receive either a Nexxt Matrixx® 3D-printed porous titanium cage or a traditional plastic PEEK cage routinely recognized as the current ‘gold standard.’ Data will be collected at 3, 6, 12, and 24 months in order to quantify the speed and quality of fusion relative to the two implant materials.

“Although often used in spinal surgery, plastic PEEK cages are limited as they function more like static shims holding expensive biologics as opposed to active scaffolds that enable endplate to endplate healing,” explains Alaedeen Abu-Mulaweh, Director of Engineering.

While other manufacturers have used 3D-printing to develop devices that mimic bone’s trabecular geometry, Nexxt Spine chose to ignore the marketing allure and focus instead on the core science.

“Titanium is physically incapable of biological remodeling, so using 3D-printing to directly mimic the structural randomness of bone doesn’t make a whole lot of sense,” explains Abu-Mulaweh. “Rather than simply looking like bone, Nexxt Matrixx® was designed with the vision of actively facilitating the body’s natural power of cellular healing.”

The initiation of the MATRIXX Trial is “a milestone moment for Nexxt Spine and the medical community as a whole,” says Elsbury. “We believe that our Nexxt Matrixx® technology has the potential to revolutionize the landscape of spinal fusion and are excited for the opportunity to prove it.”

About Nexxt Spine

Nexxt Spine, LLC is a medical device company focused on designing, manufacturing, and distributing innovative spinal solutions. The Nexxt Matrixx® family currently consists of implants available for cervical, TLIF Oblique, and TLIF procedures. Stand-Alone Cervical, Stand-Alone ALIF, and Corpectomy devices incorporating Nexxt Matrixx® technology are actively in development & testing.

Contacts

Nexxt Spine LLC
Alaedeen Abu-Mulaweh, 317-678-8424
aabu-mulaweh@nexxtspine.com

Medtronic Launches the Infinity(TM) OCT Spinal System

DUBLIN and LOS ANGELES – September 25, 2018 – Medtronic plc (NYSE:MDT) today announced the U.S. launch of the Infinity(TM) Occipitocervical-Upper Thoracic (OCT) System designed to simplify posterior cervical spine surgery. The Infinity OCT System is a complete procedural solution that integrates navigation and biologics with Medtronic’s comprehensive devices and instrumentation to create efficiency in fusion procedure workflows for the upper back and neck. The announcement was made during the North American Spine Society meeting taking place from September 26th – 29th in Los Angeles where Medtronic is exhibiting at Booth #1201.

“For more than 35 years, Medtronic has partnered with leading spine surgeons to advance new technologies with the goal of improving patient outcomes,” said Doug King, senior vice president and president of the Medtronic’s Spine division, which is part of the Restorative Therapies Group. “We engineered every component of the Infinity OCT System to perform efficiently during the most complex spine procedures, as well as to integrate seamlessly with our market-leading imaging and navigation technologies.”

The Infinity OCT System is used to immobilize and stabilize the spine while it fuses. The system features several innovative components – including a multi-axial screw with 60 degrees of angulation in any direction, a set screw (locking cap) with a quick-start thread to minimize cross threading, and 3.0mm and 5.5mm diameter screws for expanded patient demographics and clinical applications. The system has a full spectrum of implant materials and sizes – and when paired with the O-arm(TM) Imaging System and StealthStation(TM) Navigation System – provides a fully-enabled procedural solution designed to bring efficiency and simplicity to even the most complex posterior cervical procedures.

The Infinity OCT System is indicated for certain conditions including degenerative disc disease, instability or deformity, tumors, and traumatic spinal fractures or traumatic dislocations. Spine trauma can sometimes result in a spinal cord injury. September is Spinal Cord Injury Awareness Month and according to the National Spinal Cord Injury Statistical Center, the 2016 annual incidence of spinal cord injuries in the U.S. was approximately 54 cases per million people, or about 17,000 cases per year.1

“Some of our posterior cervical patients arrive in critical condition and their lives depend on our surgical skills and the performance of the tools we use to treat them,” said Dr. Greg Trost, neurosurgeon at the University of Wisconsin School of Medicine and Public Health in Madison, Wisconsin. “With Infinity, I can focus on delivering the best patient care during complex procedures knowing that every component was precisely-designed with modularity and versatility in mind. And an integrated procedural solution with Stealth navigation and Infinity was game-changing as a 3D-view of the anatomy allows me the precision to place pedicle screws with confidence and accuracy.”

The Infinity OCT System is now available in the U.S. The system will be released in geographies around the world in 2018 and 2019.

About Medtronic
Medtronic plc (www.medtronic.com), headquartered in Dublin, Ireland, is among the world’s largest medical technology, services and solutions companies – alleviating pain, restoring health and extending life for millions of people around the world. Medtronic employs more than 86,000 people worldwide, serving physicians, hospitals and patients in more than 150 countries. The company is focused on collaborating with stakeholders around the world to take healthcare Further, Together.

Any forward-looking statements are subject to risks and uncertainties such as those described in Medtronic’s periodic reports on file with the Securities and Exchange Commission. Actual results may differ materially from anticipated results.

1 Grand View Research. Spinal Implants & Devices Market Size, Share & Trends Analysis Report By Product (Fusion Devices, Spinal Biologics), By Technology, By Surgery Type, By Procedure Type, And Segment Forecasts, 2018 – 2024. April 2018. Available at: https://www.grandviewresearch.com/industry-analysis/spinal-implants-spinal-devices-market

Contacts:
Sara Thatcher
Public Relations
+1-901-399-2098

Ryan Weispfenning
Investor Relations
+1-763-505-4626

Kuros Biosciences Appoints Strategic Advisory Board

SCHLIEREN (ZURICH), Switzerland, Sept. 25, 2018 (GLOBE NEWSWIRE) — Kuros Biosciences (SIX: KURN) today announced the formation of its Strategic Advisory Board (SAB). The newly-formed SAB will work closely with Kuros’ leadership team to guide the strategic direction of the company. The SAB is assembled from key-opinion-leading surgeons and academic research experts, specialized in the treatment of disorders of the Spine. The board will sit for the first time in Los Angeles, USA on September 27, 2018, to coincide with the North American Spine Society annual meeting, at which Kuros Biosciences is presenting new scientific data in support of the Company’s bone graft product, MagnetOs, which was recently launched to market.

Joost de Bruijn, Chief Executive Officer of Kuros, said: “We are pleased to welcome some of the most recognized names in the field of spinal research onto our Strategic Advisory Board. Our SAB will provide the necessary input to ensure that we match our strategy to the needs of the market and continue to build value for the future.”

Strategic Advisory Board Members:

R. Todd Allen, MD, PhD – UCSD, San Diego, CA, US
Richard (Todd) Allen, MD, is board-certified orthopedic surgeon with expertise in complex adult reconstruction procedures for deformity/scoliosis and tumors. He also specializes in complex disorders of the upper cervical spine and in degenerative, traumatic, and post-traumatic conditions.  Dr. Allen utilizes both a variety of minimally invasive and open surgical procedures for these conditions, focused on optimizing patient-centered outcomes.  As an associate professor in the Department of Orthopedic Surgery, Dr. Allen is active in educating medical students, residents and fellows at UC San Diego School of Medicine.  He is Spine Fellowship Director at UC San Diego and actively performs research on spinal deformity, biologics, disc replacement, and cost-effective/quality metrics in spine.  He has been lead or contributing author to numerous peer-reviewed research publications and book chapters. He has presented nationally and internationally, including such meetings as our North American Spine Society (NASS) and American Academy of Orthopedic Surgeons (AAOS) meetings.  He is part of the NASS Basic Science and Biologics Committee and continues to be highly active in several national committees advancing spine surgery research and outcomes.

Alpesh A. Patel, MD, FACS – North Western Medicine, Chicago, IL, US
Alpesh A. Patel, MD is the Director of Orthopedic Spine Surgery at Northwestern and a spine surgeon with fellowship training in both Orthopedic Spine Surgery and Neurosurgery. Dr. Patel specializes in cervical spine surgery and minimally invasive spine surgery. His experience and research include the areas of cervical spine surgery, cervical myelopathy, herniated discs, minimally invasive surgery, spine trauma and spinal cord injuries. Dr. Patel is known for his clinical research on patient outcomes, genetics of spinal disease, and injuries of the spine and spinal cord. He is also known for his research in cost-effectiveness and value in spine care, making spine surgery at Northwestern, as well as throughout the United States and the world, safer and more effective.

Kornelis Poelstra, MD, PhD – Sacred Heart Hospital, FL, US
Kornelis Poelstra is board certified in orthopedic spine surgery. He specializes primarily in long-construct minimally invasive spine surgeries, adult spinal deformity, oncologic conditions, spinal fracture treatment and cervical disc replacements. He is one of the world leaders in Robotic Spine Surgery and has performed more than 600 complex robotic cases thus far. He has an extensive research background in implant associated wound infections, novel material sciences for both spine- as well as orthopedic implant designs and worked on stem cell implantation for spinal cord injury. The mechanical- and cellular processes salient for the formation of a stable arthrodesis and implant incorporation into the human body are of specific interest to him. He founded the Spine Center of Excellence at Sacred Heart Hospital in North-West Florida and has been directing this Institution since its inception.

Andrew A. Sama, MD – HSS, New York, NY, US
Dr. Andrew Sama is Associate Professor of Clinical Orthopedic Surgery at Weill Cornell Medical College and previously served as Director of Spine Surgery Fellowship at Hospital for Special Surgery. Dr. Andrew Sama specializes in the management of all traumatic, degenerative, and deformity-related conditions of the cervical, thoracic, and lumbosacral spine. He has received several research grants, including funding from the National Institutes of Health. Dr. Sama is involved in product development and has helped design several orthopedic implant devices. He has published articles in numerous peer-reviewed medical journals and co-edited a textbook titled ‘Lateral Access Minimally Invasive Spine Surgery’. He is on the editorial board of Current Reviews in Musculoskeletal Medicine and serves as a reviewer for the journals Spine and Clinical Orthopedics and Related Research.

Faheem Sandhu, MD, PhD – MedStar Health, Chevy Chase, MD, US
Faheem Sandhu, MD, PhD, is director of Spine Surgery at MedStar Georgetown University Hospital and professor of Neurological Surgery at Georgetown University Medical Center. He specializes in minimally invasive and complex spinal surgery. Dr. Sandhu is an innovator in the field and holds several patents. His practice includes all areas of spine conditions: degenerative, deformity, tumor, and trauma. He has special interest in minimally invasive spine surgery and applying these techniques to all aspects of spinal surgery as well as disc arthroplasty and disorders of the craniocervical junction. Dr. Sandhu has authored more than 50 peer-reviewed articles and book chapters and has presented his research at major meetings in the U.S. and abroad. He regularly teaches courses on techniques of minimally invasive spine surgery. He is a Diplomate of the American Board of Neurological Surgeons and a Fellow of the American Association of Neurological Surgeons.

Prof. Bill Walsh PhD – UNSW, Sydney, Australia 
W.R. Walsh, Ph.D. is a Professor in the Prince of Wales Clinical School, Division of Surgery at University of New South Wales in Sydney, Australia, and Director of Surgical & Orthopaedic Research Laboratories, Prince of Wales Hospital. His research lies at the interface between implanted materials, including autograft, allograft and synthetic biomaterials, and the connective tissues of the body. The foundation of his research interests center on understanding the biology and biomechanics of connective tissues during healing, age and disease; this involves research techniques from the macro to molecular level. Bill has over 385 peer reviewed journal publications, book chapters and patents. He is on several editorial boards including Biomaterials, CORR, Muscle Tendon Ligament Journal, Journal of Biomechanics, The Spine Journal and Frontiers in Surgery and Bone and Joint Research.

For further information, please contact:
Kuros Biosciences AG Media & Investors
Michael Grau Hans Herklots
Chief Financial Officer LifeSci Advisors
Tel +41 44 733 47 47 +41 79 598 7149
michael.grau@kurosbio.com hherklots@lifesciadvisors.com

About MagnetOs
MagnetOs promotes local bone formation equivalent to current gold standard, autograft. MagnetOs is a bone graft substitute intended to fill bony voids or gaps of the human skeletal system and promote the formation of bone at the implanted site. A substantial number of clinically relevant and predictive studies have demonstrated its equivalence to the current gold standard (patient’s own bone, which may not be available in sufficient quantities and/or involves morbidity, costs and pain associated with its harvesting from another healthy site of the patient’s body). MagnetOs is a bone graft comprising biphasic calcium phosphate with an advanced submicron surface topography that directs bone formation after implantation. With its unique submicron surface topography, MagnetOs preferentially directs early wound healing toward the bone-forming pathway, resulting in an osteoinductive claim in Europe. MagnetOs is available as granules and as a putty formulation.

About Kuros Biosciences AG 
Kuros Biosciences (SIX:KURN) is focused on the development of innovative products for bone regeneration and is located in Schlieren (Zurich), Switzerland and Bilthoven, The Netherlands. Visit www.kurosbio.com for additional information on Kuros, its people, science and product pipeline.

Forward Looking Statements 
This media release contains certain forward-looking statements that involve risks and uncertainties that could cause actual results to be materially different from historical results or from any future results expressed or implied by such forward-looking statements. You are urged to consider statements that include the words “will” or “expect” or the negative of those words or other similar words to be uncertain and forward-looking. Factors that may cause actual results to differ materially from any future results expressed or implied by any forward-looking statements include scientific, business, economic and financial factors. Against the background of these uncertainties, readers should not rely on forward-looking statements. The Company assumes no responsibility for updating forward-looking statements or adapting them to future events or developments.

RTI Surgical® Wins 2018 Orthopedics This Week Spine Technology Award for TETRAfuse® 3D Technology

September 25, 2018

LOS ANGELES–(BUSINESS WIRE)–RTI Surgical, Inc. (Nasdaq:RTIX), a global surgical implant company, announced its TETRAfuse® 3D Technology won a 2018 Spine Technology Award from Orthopedics This Week, a widely read publication in the orthopedics industry. RTI will accept the award at the North American Spine Society’s (NASS) 33rd Annual Meeting taking place September 26-29, 2018 in Los Angeles and will be featured in upcoming issues of Orthopedics This Week and Orthopedics This Month Spine.

“RTI is honored to receive this important industry recognition, which is a testament to the ingenuity and dedication of our employees,” said Camille Farhat, President and CEO, RTI Surgical. “TETRAfuse 3D Technology is one of many examples of RTI’s commitment to the development and ongoing clinical research of innovative spine-focused solutions that meet the demands of surgeons and improve patient outcomes around the world.”

TETRAfuse 3D Technology is an interbody fusion (IBF) device material, manufactured under an exclusive license with Oxford Performance Materials, designed to help drive optimal outcomes for patients undergoing spinal fusion procedures. It is the first 3D printed polymer-based IBF device material to incorporate a nano-roughisurface that has demonstrated, in a pre-clinical study, more notable trabecular bone ingrowth compared to PEEK and titanium-coated PEEK.ii

TETRAfuse 3D Technology is featured in RTI’s growing Fortilink® series of devices, including the Fortilink-C, -TS and -L IBF Systems. The devices are intended for use in interbody fusion procedures in patients with degenerative disc disease (DDD), an age-related condition when one or more discs between the vertebrae of the spinal column deteriorate or break down, which can lead to pain.iii

Those attending NASS can visit Booth #1523 to learn more about the Fortilink series of devices featuring TETRAfuse 3D Technology, as well as RTI’s full line of high-quality hardware, interbody and orthobiologic spine offerings. For more information about the Fortilink IBF series of devices and TETRAfuse 3D Technology, visit www.tetrafuse3D.com.

About Orthopedics This Week

Orthopedics This Week delivers breaking news, analysis and commentary to professionals working in the orthopedics industry. Published 40 times a year, Orthopedics This Week is a four-time winner of the MORE awards for journalistic excellence. Each year, Orthopedics This Week grants the Spine Technology Awards to inventors, engineering teams, surgeons and their companies who have created the most innovative, enduring and practical products in the treatment or care of the spine. Submissions are judged by a panel of leading surgeons with extensive clinical and research experience in spinal care.

About RTI Surgical, Inc.

RTI Surgical is a leading global surgical implant company providing surgeons with safe biologic, metal and synthetic implants. Committed to delivering a higher standard, RTI’s implants are used in sports medicine, general surgery, spine, orthopedic and trauma procedures and are distributed in nearly 50 countries. RTI has four manufacturing facilities throughout the U.S. and Europe. RTI is accredited in the U.S. by the American Association of Tissue Banks and is a member of AdvaMed. For more information, please visit www.rtix.com. Connect with us on LinkedIn and Twitter.

Forward-Looking Statements

This communication contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. These forward-looking statements are based on management’s current expectations, estimates and projections about our industry, our management’s beliefs and certain assumptions made by our management. Words such as “anticipates,” “expects,” “intends,” “plans,” “believes,” “seeks,” “estimates,” variations of such words and similar expressions are intended to identify such forward-looking statements. In addition, except for historical information, any statements made in this communication about anticipated financial results, growth rates, new product introductions, future operational improvements, gaining market share and results or regulatory actions or approvals or changes to agreements with distributors also are forward-looking statements. These statements are not guarantees of future performance and are subject to risks and uncertainties, including the risks described in public filings with the U.S. Securities and Exchange Commission (SEC). Our actual results may differ materially from the anticipated results reflected in these forward-looking statements. Copies of the company’s SEC filings may be obtained by contacting the company or the SEC or by visiting RTI’s website at www.rtix.com or the SEC’s website at www.sec.gov.

i Data on file at RTI Surgical, Inc.
ii Data on file at RTI Surgical, Inc. Performance data from animal studies may not be representative of performance in humans.
iii Donally C, Dulebohn S; Lumbar Degenerative Disk Disease. StatPearls. 2017 Oct 13. Available at https://www.ncbi.nlm.nih.gov/books/NBK448134/

Contacts

RTI Surgical, Inc.
Media Contacts:
Annie Claggett, +1 312-995-2856
aclaggett@rtix.com
or
Molly Poarch, +1 224-287-2661
mpoarch@rtix.com
or
Investor Contact:
Nathan Elwell, +1 847-530-0249

nelwell@lincolnchurchilladvisors.com

Arkansas Surgical Hospital Announces New Procedure for Neck and Arm Pain

Arkansas Surgical Hospital is now offering patients who suffer from neck and arm pain a new, minimally-invasive procedure. The prodisc C Anterior Cervical Total Disc Replacement surgery uses a ball-and-socket implant designed to maintain range of motion in the spine while removing the patient’s diseased disc.

“This procedure is similar to the way we’ve been replacing hips and knee joints over the years,” said Phillip M. Porcelli, D.O., FACOS. “Applying this same technique to the spine allows us to address the patient’s back pain without impeding their mobility or range of motion. We’re able to replace a degenerated or diseased disc with an artificial implant that improves the patient’s natural spinal motion.”

The prodisc system is the most studied Total Disc Replacement System in the United States. Over 200 peer-reviewed studies have been conducted on the system. The initial prodisc C IDE clinical study evaluated the prodisc C Total Disc Replacement surgery compared to spinal fusion surgery. The study demonstrated that prodisc C surgery is a safe and effective alternative to fusion surgery for qualified patients.

“Before total disc replacement became available our options were often limited,” said Dr. Porcelli. “We would have to remove the diseased disc and fuse the vertebrae above and below together. This left the patient with reduced range of motion and increased the likelihood of more spine surgeries.”

ABOUT ARKANSAS SURGICAL HOSPITAL 
Arkansas Surgical Hospital was founded in 2005 by a group of surgeons who wanted to provide high quality, patient focused care. As a physician-owned facility, the surgeons make the decisions that impact every level of patient care.

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Tobra Medical Announces National Launch of Tobra Bone Basket for Collection of Drilled Autograft Bone in Spine Surgery

WAKE FOREST, NC / ACCESSWIRE / September 24, 2018 / Tobra Medical Inc., a specialty medical device company focused on autograft bone and specimen collection, today announced the national launch of the Tobra Bone Basket, a user friendly, continuous filtration, mesh basket system that maximizes collection of autograft bone during high speed bone drilling, for use as a bone graft. The national launch of the Tobra Bone Basket coincides with the exhibit debut (Booth #1163) at this week’s North American Spine Society (NASS) meeting in Los Angeles, CA.

”During the past six-month, market focused pilot launch, spine surgeons have consistently commented that the Tobra Bone Basket is easy to use, does not interrupt their surgery, and collects a tremendous amount of autograft bone. Additionally, the handling characteristics of the collected autograft bone output are workable, moldable and manageable for spine surgeons,” said Tobra Medical Founder and President Brad Collins.

Mr. Collins continued, ”Hospitals, surgery centers, hospital networks, and group purchasing organizations have welcomed the Tobra Bone Basket due to its economic value and cost savings associated with the reduction and elimination of expensive allograft bone substitutes in use today . The Tobra Bone Basket assists the surgeon’s need for providing autologous bone to the fusion process and to the facility’s interest in reducing cost for expensive allograft bone substitutes.”

The key component of the patented Tobra Bone Basket is the unique removeable mesh basket. The size and pattern of the mesh basket has been specifically designed and tested to capture drilled bone particles, while allowing for a continuous non-stop filtration of blood and irrigation fluids. The 25mL mesh basket is removable for easy transport of autograft bone with minimal direct handling of bone output. The inversion capability of the mesh basket ensures complete retrieval of all bone particles, thus maximizing the output with little to no waste. The Tobra Bone Basket plunger helps to further assist bone particle separation when pressed by eliminating excess fluid from autograft bone and allowing for a workable output that is easy to use and manipulate.

For more information, please visit www.tobrabonebasket.com

About Tobra Medical

Tobra Medical is headquartered in Wake Forest, NC and is a specialty medical device company focused on autograft bone and specimen collection devices for use in the operating room. Founded in 2015 with a vision to innovate effective and economical autograft bone and specimen collection systems, Tobra Medical launched their first products in January 2018. Located in the Research Triangle Region of North Carolina, Tobra Medical leverages a collaboration of high performing medical engineers, surgeons, and operating room personnel to innovate solutions to improve better clinical patient outcomes. For more information, visit www.tobramedical.com or email info@tobramedical.com.

Contact:

info@tobramedical.com
(866) 777-1505

SOURCE: Tobra Medical Inc.